Pineal Vasotocin: Release into Cat Cerebrospinal Fluid by Melanocyte-Stimulating Hormone Release-Inhibiting Factor

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Science  08 Jul 1977:
Vol. 197, Issue 4299, pp. 179-180
DOI: 10.1126/science.197.4299.179


The intracarotid injection of both synthetic melanocyte-stimulating hormone release-inhibiting factor (MIF) and purified MIF prepared from bovine hypothalami induces arginine vasotocin release into cerebrospinal fluid of cats and significantly decreases the pineal arginine vasotocin content at 5 minutes after the injection. The present results demonstrate an extrapituitary endocrine effect of synthetic and purified bovine MIF.