Haloperidol: effect of long-term treatment on rat striatal dopamine synthesis and turnover

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Science  08 Jul 1977:
Vol. 197, Issue 4299, pp. 181-183
DOI: 10.1126/science.17917


The short- and long-term effects of neuroleptic drugs differ both clinically and biochemically. Short-term treatment with such a drug causes a kinetic activation of striatal tyrosine hydroxylase. Long-term treatment causes a prompt activation of the enzyme which is followed by a delayed, compensatory deactivation below control levels. Tolerance also develops to the stimulating effect of haloperidol on striatal dopamine turnover.