A bactericidal effect for human lactoferrin

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Science  15 Jul 1977:
Vol. 197, Issue 4300, pp. 263-265
DOI: 10.1126/science.327545


Streptococcus mutans and Vibrio cholerae, but not Escherichia coli, were killed by incubation with purified human apolactoferrin. Concentrations of lactoferrin below that necessary for total inhibition resulted in a marked reduction in viable colony-forming units. This bactericidal effect was contingent upon the metal-chelating properties of the lactoferrin molecule.

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