Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity

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Science  05 Aug 1977:
Vol. 197, Issue 4303, pp. 596-598
DOI: 10.1126/science.877576


The binding of [3H]haloperidol to rat striatal dopamine receptors increases after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which are behaviorally supersensitive, as reflected by apomorphine-induced contralateral rotations. The enhanced binding is associated with an increased number of receptor sites with no change in their affinity.