Structure of a molluscan cardioexcitatory neuropeptide

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Science  12 Aug 1977:
Vol. 197, Issue 4304, pp. 670-671
DOI: 10.1126/science.877582


A cardioexcitatory substance from ganglia of the clam Macrocallista nimbosa, formerly designated peak C, is the tetrapeptide amide Phe-Met-Arg-Phe-NH2. Its structure was determined by the combined use of Edman dansyl degradation and tryptic digestion. The structure was confirmed by synthesis. This neuropeptide is active at about 10(-8)M when assayed on molluscan muscle.

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