Defective phagocytosis of isolated rod outer segments by RCS rat retinal pigment epithelium in culture

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Science  02 Sep 1977:
Vol. 197, Issue 4307, pp. 1001-1003
DOI: 10.1126/science.560718


Retinal pigment epithelium cultured from normal rats phagocytizes large amounts of rod outer segment fragments isolated from normal rats and from RCS rats with inherited retinal degeneration. Cultured RCS rat pigment epithelium rarely ingests outer segment material, although the cells extend cellular processes around fragments of either type. Both normal and RCS pigment epithelium phagocytize polystyrene spheres. This demonstrates that RCS rat pigment epithelial cells contain a defect in the mechanism for phagocytizing outer segments.