Naturally occurring plasmid carrying genes for enterotoxin production and drug resistance

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Science  14 Oct 1977:
Vol. 198, Issue 4313, pp. 198-199
DOI: 10.1126/science.333581


Escherichia coli strain 86, isolated from a piglet with diarrhea, carries plasmid-linked genes for resistance to tetracycline, streptomycin, and sulfonamides and for production of heat-labile and heat-stable enterotoxin. Results of (i) genetic experiments involving conjugal transfer and phage P1-mediated transduction and (ii) physical experiments involving electron microscopic examination of plasmid DNA and heteroduplex analysis show that a single conjugative plasmid carries the genes for drug resistance and production of enterotoxin.

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