Methylphenidate in hyperkinetic children: differences in dose effects on learning and social behavior

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Science  23 Dec 1977:
Vol. 198, Issue 4323, pp. 1274-1276
DOI: 10.1126/science.337493


Methylphenidate (Ritalin) is widely prescribed for hyperkinetic children. This study showed a peak enchancement of learning in children after being given a dose of 0.3 milligram per kilogram of body weight, and a decrement in learning in those given larger doses; social behavior showed the most improvement in children given 1.0 milligram per kilogram. These results had been hypothesized from theoretical dose-response curves which indicate different target behaviors would improve at different doses.

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