Thyroid Gangliosides with High Affinity for Thyrotropin: Potential Role in Thyroid Regulation

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Science  06 Jan 1978:
Vol. 199, Issue 4324, pp. 77-79
DOI: 10.1126/science.199.4324.77


Thyroid cell membranes contain a multiplicity of gangliosides, some of which inhibit thyrotropin binding to thyroid membranes. The most potent inhibitor is a ganglioside which is present in only trace amounts and appears to have a novel structure. Thyroid gangliosides may play a role in relaying the hormonal message to the thyroid cell.