Rabies viruses increase in virulence when propagated in neuroblastoma cell culture

See allHide authors and affiliations

Science  10 Mar 1978:
Vol. 199, Issue 4333, pp. 1072-1075
DOI: 10.1126/science.628831


Several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. The virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems.