Nonhistone proteins HMG1 and HMG2 change the DNA helical structure

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Science  24 Mar 1978:
Vol. 199, Issue 4335, pp. 1345-1346
DOI: 10.1126/science.628842


Two chromatin nonhistone proteins (from calf thymus) of the high mobility group, HMG1 and HMG2, reduce the linking number (topological winding number) of a circular DNA if the covalent closure of the DNA is carried out in their presence. This indicates that these proteins can either unwind the double helix, or induce a supercoiling of the DNA.

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