Schizophrenic symptoms improve with apomorphine

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Science  05 May 1978:
Vol. 200, Issue 4341, pp. 567-568
DOI: 10.1126/science.347574


Eighteen chronic schizophrenic patients received subcutaneous doses of apomorphine, a dopamine receptor agonist, and of placebo in separate trials. A significant improvement in psychotic symptoms occurred after apomorphine compared to placebo. The results are interpreted as a consequence of presynaptic dopamine receptor activation by apomorphine with a subsequent decrease in dopamine-mediated neural transmission.

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