Viremia in experimental Creutzfeldt-Jakob disease

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Science  02 Jun 1978:
Vol. 200, Issue 4345, pp. 1069-1071
DOI: 10.1126/science.349691


Inoculation of the buffy coat of blood from guinea pigs infected with Creutzfeldt-Jakob disease resulted in passage of this disease to recipient animals. This demonstrates that there is a viremia in experimental Creutzfeldt-Jakob disease. These findings suggest that the hematogenous route may be implicated in the human infection and that the disease may possibly be transmitted by blood transfusions.