Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food

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Science  21 Jul 1978:
Vol. 201, Issue 4352, pp. 262-264
DOI: 10.1126/science.566469


The dopamine receptor blocker pimozide attenuated lever-pressing and running for food reward in hungry rats. In each case the characteristic behavior of pimozide-treated rats was the same as that of undrugged rats when reward was simply withheld. Drug-induced performance difficulties were ruled out by the presence of periods of normal responding in drug-treated animals. Pimozide appears to selectively blunt the rewarding impact of food and other hedonic stimuli.

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