Suppression of chronic allergic encephalomyelitis: relevance to multiple sclerosis

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Science  04 Aug 1978:
Vol. 201, Issue 4354, pp. 445-448
DOI: 10.1126/science.78524


The expression of chronic relapsing experimental allergic encephalomyelitis in strain 13 guinea pigs was suppressed with a single series of injections of myelin basic protein in incomplete Freund's adjuvant. The suppression appeared permanent, and subsequent rechallenge with central nervous system antigen failed to elicit exacerbations.