Lymphocyte ecto-5'-nucleotidase deficiency in agammaglobulinemia

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Science  18 Aug 1978:
Vol. 201, Issue 4356, pp. 628-630
DOI: 10.1126/science.27864


Fresh peripheral blood lymphocytes from eight patients with congenital agammaglobulinemia demonstrate reduced ecto-5'-nucleotidase activity when compared to the mean activity of normal subjects and patients with other forms of immunoglobulin deficiency. A specific defect of ecto-5'-nucleotidase is further suggested by normal values for lymphocyte ecto-adenosinetriphosphatase and ecto-nonspecific phosphatase. The data provide evidence for an enzyme deficiency in this X-linked, B lymphocyte deficiency syndrome.

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