Bone marrow origin of hepatic macrophages (Kupffer cells) in humans

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Science  08 Sep 1978:
Vol. 201, Issue 4359, pp. 937-938
DOI: 10.1126/science.356266


Hepatic macrophages (Kupffer cells) from two male recipients of bone marrow transplants from females were studied for fluorescent Y body staining and sex chromatin (Barr body). After the transplant, macrophages had the sex karyotype of the donor, indicating that human hepatic macrophages originate in bone marrow.