Localization of inorganic phosphate in the pancreatic B cell and its loss on glucose stimulation

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Science  22 Sep 1978:
Vol. 201, Issue 4361, pp. 1124-1126
DOI: 10.1126/science.356269


Perifusion experiments have shown that there is a discharge of inorganic phosphate into the medium when insulin secretion from isolated islets is stimulated by glucose. Histochemical and microprobe examination of resting pancreatic islets in the electron microscope shows a specific accumulation of inorganic phosphate adjacent to the plasmalemma and nucleolus of the B (beta) cells. This phossphate is lost from the cells during secretory stimulation of islets with high concentrations of glucose.

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