Prenatal exposure to prednisone in humans and animals retards intrauterine growth

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Science  27 Oct 1978:
Vol. 202, Issue 4366, pp. 436-438
DOI: 10.1126/science.705336


Prednisone treatment for infertility and subsequent pregnancy maintenance in humans resulted in a significant decrease in the birth weight of full-term infants and a marked increase in the percentage of newborn infants weighing 2500 grams or less, that is, "light for dates" in comparison to control offspring. A parallel experiment with mice indicated that the reduction of birth weight was caused by exposure to corticosteroids rather than to maternal disease or malfunction.

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