Angiotensin regulates release and synthesis of serotonin in brain

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Science  08 Dec 1978:
Vol. 202, Issue 4372, pp. 1091-1093
DOI: 10.1126/science.152460


Angiotensin II released serotonin from neuron terminals and accelerated synthesis of the serotonin. This increase in synthesis depended on the activation of tryptophan hydroxylase. A biphasic effect was observed: at high doses the stimulatory effect depended on conversion of angiotensin II to angiotensin III. At low doses an inhibitory effect was found, possible dependent on an angiotensin II metabolite. These actions represent a subtle regulation of the open-loop serotonin system.

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