Human skin fibroblasts derived from papillary and reticular dermis: differences in growth potential in vitro

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Science  04 May 1979:
Vol. 204, Issue 4392, pp. 526-527
DOI: 10.1126/science.432659


Papillary fibroblasts, when compared to reticular fibroblasts from the same skin specimen, exhibit greater proliferative capacities in vitro. These results demonstrate a difference in function between morphologically similar cells obtained from the same tissue. Such findings represent an important consideration in the study of cell aging in vitro.