4-aminobutyrate:2-oxoglutarate aminotransferase in blood platelets

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Science  17 Aug 1979:
Vol. 205, Issue 4407, pp. 696-698
DOI: 10.1126/science.462176


Platelet lysates obtained from blood of humans, dogs, and rats catalyzed the transamination of 4-aminobutyrate with 2-oxoglutarate as cosubstrate. Human platelet 4-aminobutyrate:2-oxoglutarate aminotransferase (36.5 +/- 3.2 picomoles per minute per milligram of platelet protein) resembled the brain enzyme in kinetic properties and in response to cofactors and inhibitors.