Drug discrimination training with progressively lowered doses

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Science  17 Aug 1979:
Vol. 205, Issue 4407, pp. 720-721
DOI: 10.1126/science.462182


Rats were trained to discriminate drug from no-drug conditions in a two-lever operant task. Moderately high dosages were used initially. Whenever the discrimination was learned, training was continued with progressively reduced dosages. Eventually the rats discriminated extremely low doses of phenobarbital, chlordiazepoxide, cyclazocine, and fentanyl.