Mullerian duct regression in the embryo correlated with cytotoxic activity against human ovarian cancer

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Science  31 Aug 1979:
Vol. 205, Issue 4409, pp. 913-915
DOI: 10.1126/science.472712


A significant cytotoxicity index was obtained when human ovarian cancer cells in a microcytotoxicity assay were exposed during the S (DNA-synthesizing) phase of the cell cycle to purified fractions of testis exhibiting high Mullerian inhibiting substance bioactivity. The same effect was not observed when these fractions were tested against human glioblastoma or fibroblast lines. Most human ovarian cancers are said to resemble Mullerian tissues histologically. Mullerian inhibiting substance may thus deserve further study as a potential chemotherapeutic agent.

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