Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey

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Science  31 Aug 1979:
Vol. 205, Issue 4409, pp. 929-932
DOI: 10.1126/science.112679


Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed alternation performance nearly as severe as that caused by surgical ablation of the same area. This behavioral deficit can be pharmacologically reversed with dopamine agonists such as L-dopa and apomorphine. These data provide direct evidence that dopamine plays an important role in a specific cortical function.

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