Chronic zinc deficiency alters neuronal function of hippocampal mossy fibers

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Science  07 Sep 1979:
Vol. 205, Issue 4410, pp. 1005-1007
DOI: 10.1126/science.224456


Low-frequency stimulation of hippocampal mossy fiber axons in zinc-deficient adult rats produced synaptic responses that declined in amplitude with successive stimuli. This response decrement is abnormal and suggests that the heavy deposits of zinc in mossy fiber boutons are important for synaptic transmission.