Meiotic maturation in Xenopus laevis oocytes initiated by insulin

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Science  28 Sep 1979:
Vol. 205, Issue 4413, pp. 1397-1399
DOI: 10.1126/science.472755


Insulin can induce meiotic division in Xenopus laevis oocytes. This effect shows the specificity expected of a receptor-mediated mechanism. It is potentiated by ethynylestradiol, a steroid antagonist of pregesterone (the natural hormone that provokes meiosis). The Xenopus laevis oocytes may serve as a model for the study of the poorly understood effect of insulin on cell division.