Antipsychotic drug action in schizophrenic patients: effect on cortical dopamine metabolism after long-term treatment

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Science  28 Sep 1979:
Vol. 205, Issue 4413, pp. 1405-1407
DOI: 10.1126/science.38504


In the brains of deceased schizophrenics who underwent long-term treatment with antipsychotic drugs, the concentration of homovanillic acid (a dopamine metabolite) was significantly increased in the orbital frontal, cingulate, and temporal tip areas of the cortex, but not in the putamen or the nucleus accumbens. The concentration of homovanillic acid was normal in the brains of schizophrenics who were not treated with drugs.