Angiogenesis in the mouse cornea

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Science  28 Sep 1979:
Vol. 205, Issue 4413, pp. 1416-1418
DOI: 10.1126/science.472760


We have developed a method that permits analysis of neovascular responses in the mouse cornea. Using this method we have demonstrated that both allogeneic lymphocytes and a variety of tumors can induce angiogenesis, but that only the latter appear capable of eliciting secondary capillary sprouting.