Imbalance in X-chromosome expression: evidence for a human X-linked gene affecting growth of hemopoietic cells

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Science  28 Sep 1979:
Vol. 205, Issue 4413, pp. 1418-1420
DOI: 10.1126/science.472761


In each of six family members who were heterozygous at the X-linked locus for glucose-6-phosphate dehydrogenase, only one or the other of the two alleles at that locus was almost exclusively expressed. The data are consistent with evidence that X-chromosome inactivation is a random process that may be followed by selection for one of the two resulting cell types on the basis of an unknown gene, which is located on the X chromosome and which can affect the rate of proliferation of hemopoietic cells in humans.