Monoclonal antibodies defining distinctive human T cell surface antigens

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Science  19 Oct 1979:
Vol. 206, Issue 4416, pp. 347-349
DOI: 10.1126/science.314668


Three novel nonoclonal antibodies (designed OKT1, OKT3, and OKT4) were generated against surface determinants of human peripheral T cells. Both OKT1 and OKT3 reacted with all human peripheral T cells and 5 to 10 percent of thymocytes but differed in their reactivities with T cel- lines. By contrast, OKT4 reacted with 55 percent of human peripheral T cells and 80 percent of thymocyted in that they did not react with normal B cells, null cells, monocytes, or granulocytes.

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