Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter

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Science  30 Nov 1979:
Vol. 206, Issue 4422, pp. 1089-1091
DOI: 10.1126/science.493994


Wild-type Chinese hamster V79 cells (6-thioguanine-sensitive) reduce the recovery of 6-thioguanine-resistant cells when they are cultured together at high densities, through a form of intercellular communication (metabolic cooperation). Cooperation is inhibited by 12-O-tetradecanoyl phorbol-13-acetate, rescuing the 6-thioguanine-resistant cells. These results may be useful in the study of an aspect of the mechanism of tumor promotion and in assaying for promoters.