A glucose-controlled insulin-delivery system: semisynthetic insulin bound to lectin

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Science  07 Dec 1979:
Vol. 206, Issue 4423, pp. 1190-1191
DOI: 10.1126/science.505005


A stable, biologically active glycosylated insulin derivative that is complementary to the major combining site of concanavalin A has been synthesized. Hormone release is proportional to the quantity of glucose present. Glucose regulation of exogenous insulin delivery could have important applications in the therapy of diabetes mellitus.

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