Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes

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Science  21 Dec 1979:
Vol. 206, Issue 4425, pp. 1421-1423
DOI: 10.1126/science.388619


Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morpholigic and physiologic characteristics of human insulin-dependent diabetes mellitus.

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