Hybridoma produces protective antibodies directed against the sporozoite stage of malaria parasite

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Science  04 Jan 1980:
Vol. 207, Issue 4426, pp. 71-73
DOI: 10.1126/science.6985745


Hybrid cells secreting antibodies against sporozoites of Plasmodium berghei were obtained by fusion of plasmacytoma cells with immune murine spleen cells. The monoclonal antibodies bound to a protein with an apparent molecular weight of 44,000 (Pb44), which envelopes the surface membrane of sporozoites. Incubation of sporozoites in vitro with antibodies to Pb44 abolished their infectivity.