Successful culture of rat embryos on human serum: use in the detection of teratogens

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Science  28 Mar 1980:
Vol. 207, Issue 4438, pp. 1471-1473
DOI: 10.1126/science.7361097


Growth of head-fold-stage rat embryos cultured with human serum for 48 hours was enhanced by supplementation with glucose. Embryo growth (protein and DNA contents) varied with the source of the serum. Serum from 16 of 19 untreated subjects produced normal embryos. Serum from five subjects undergoing cancer chemotherapy and six subjects receiving anticonvulsants was either lethal or teratogenic.