X-ray and neutron scattering density profiles of the intact human red blood cell membrane

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Science  28 Mar 1980:
Vol. 207, Issue 4438, pp. 1481-1483
DOI: 10.1126/science.7361101


Hemoglobin-free human red blood cell membranes have been prepared with glutaraldehyde to maintain an intact structure on partial dehydration. Treatment of resealed ghosts with poly(L-lysine) produced an essentially constant structural unit and permitted correlation of electron microscopy results with x-ray and neutron diffraction profiles. These profiles provide detailed information, for the intact membrane, on the location and relative distribution of lipids and proteins.