Vertical transmission of acquired ulcer susceptibility in the rat

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Science  06 Jun 1980:
Vol. 208, Issue 4448, pp. 1161-1163
DOI: 10.1126/science.7189606


Premature separation of rat pups from their dams greatly increases their susceptibility to restraint-induced gastric erosions. When prematurely separated female rats grow to adulthood and mate with stock males, their normally reared F 1 progeny also have increased susceptibility to restraint-induced erosions. Cross-fostering studies show that prenatal rather than postnatal factors transmit this susceptibility to the F 1 progeny.

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