Kindling induces long-lasting alterations in response of hippocampal neurons to elevated potassium levels in vitro

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Science  13 Jun 1980:
Vol. 208, Issue 4449, pp. 1264-1265
DOI: 10.1126/science.7375936


The cellular basis of kindling was studied electrophysiologically with slices of guinea pig hippocampus. Normally, epileptiform activity can be induced in the slices only by combined exposure to elevated potassium levels and a chemical convulsant such as penicillin. In hippocampal slices from pentylenetetrazole-kindled animals, however, elevated potassium alone can induce seizures. These data suggest that kindling elicits long-term changes in neuronal excitability that may involve ionic mechanisms.