Electrical activity in an exocrine gland: optical recording with a potentiometric dye

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Science  13 Jun 1980:
Vol. 208, Issue 4449, pp. 1269-1271
DOI: 10.1126/science.7375937


Propagated action potentials in the salivary gland of a freshwater snail were detected by optical means. Voltage-dependent absorption changes from acinar cells stained with a merocyanine-oxazolone dye faithfully reproduced the time course of electrical activity in this tissue. Such signals may provide a useful tool for the study of endocrine tissue as well.