Evidence for a vesicular transport mechanism in hepatocytes for biliary secretion of immunoglobulin A

See allHide authors and affiliations

Science  13 Jun 1980:
Vol. 208, Issue 4449, pp. 1276-1278
DOI: 10.1126/science.7375938


Quantitative electron microscopic autoradiography and diaminobenzidine cytochemistry provide evidence for an uptake and vesicular transport mechanism for iodine-125-labeled immunoglobulin A from plasma to bile by hepatocytes in vivo. The data confirm the existence of a hepatobiliary pathway for secretion of immunoglobulin A into the intestine and are consistent with a vesicular transport mechanism for biliary proteins within liver parenchymal cells.