Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro

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Science  18 Jul 1980:
Vol. 209, Issue 4454, pp. 394-395
DOI: 10.1126/science.7384811


Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance.

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