Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen

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Science  25 Jul 1980:
Vol. 209, Issue 4455, pp. 497-499
DOI: 10.1126/science.6248960


Analysis of the cell culture fluid from two new human hepatoma-derived cell lines reveals that 17 of the major human plasma proteins are synthesized and secreted by these cells. One of these cell lines, Hep 3B, also produces the two major polypeptides of the hepatitis B virus surface antigen. When Hep 3B in injected into athymic mice, metastatic hepatocellular carcinomas appear. These cell lines provide experimental models for investigation of plasma protein biosynthesis and the relation of the hepatitis B viru genome to tumorigenicity.

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