Limitations of metabolic activation systems used with in vitro tests for carcinogens

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Science  25 Jul 1980:
Vol. 209, Issue 4455, pp. 503-505
DOI: 10.1126/science.6771871


Important differences between the metabolic activation of 7,12-dimethylbenz[a]anthracene in intact cellular systems and in liver homogenates suggest that the use of homogenates in conjunction with short-term assays for carcinogens could yield misleading results.