Carcinogenic activity of particulate nickel compounds is proportional to their cellular uptake

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Science  25 Jul 1980:
Vol. 209, Issue 4455, pp. 515-517
DOI: 10.1126/science.7394519


Particles (less than or equal to 5 micrometers) of the potent carcinogen crystalline nickel subsulfide were actively phagocytized by cultures of Syrian hamster embryo cells and Chinese hamster ovary cells. Cells did not take up significant quantities of similar-sized particles of the noncarcinogen amorphous nickel monosulfide. The carcinogenic activity of this and other metal compounds appears to be proportional to their cellular uptake.