Excitatory and inhibitory effects of serotonin on sensorimotor reactivity measured with acoustic startle

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Science  25 Jul 1980:
Vol. 209, Issue 4455, pp. 521-523
DOI: 10.1126/science.7394520


Serotonin infused into the lateral ventricle in rats produced a dose-dependent depression of the acoustic startle reflex. When infused onto the spinal cord, serotonin produced a dose-dependent increase in startle. Thus the same neurotransmitter can modulate the same behavior in opposite ways, depending on which part of the central nervous system is involved.