Gap junction development is correlated with insulin content in the pancreatic B cell

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Science  29 Aug 1980:
Vol. 209, Issue 4460, pp. 1026-1028
DOI: 10.1126/science.6773144


The development of gap junctions between insulin-containing B cells was quantitatively analyzed in islets of Langerhans isolated from rats treated with the sulfonylurea glibenclamid for 1, 2, or 7 days. Glibenclamid treatment was associated with a marked depletion of the insulin content of B cells and with an increase in the number and size of gap junctions between these cells. A significance correlation was found between these two events.

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