Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors

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Science  24 Oct 1980:
Vol. 210, Issue 4468, pp. 441-443
DOI: 10.1126/science.6254143


Incubation of astrocytoma cells with catecholamines results in a decrease in catecholamine-stimulated adenylate cyclase activity and a concomitant alteration in the sedimentation properties of particulate beta-adrenergic receptors. The altered receptors exhibit agonist binding properties similar to those of receptors that are "uncoupled" from adenylate cyclase.

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