Antibody targeting of liposomes: cell specificity obtained by conjugation of F(ab')2 to vesicle surface

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Science  31 Oct 1980:
Vol. 210, Issue 4469, pp. 539-541
DOI: 10.1126/science.7423203


A method devised for conjugating liposomes with protein resulted in the binding of up to 200 micrograms of immunoglobulin G per micromole of lipid. The coupling of antibody to human erythrocyte F(ab')2 in vesicles (140 molecules per vesicle) by this method caused a 200-fold increase in the binding of vesticles to human erythrocytes and resulted in about 80 percent of the vesicle lipid and contents being associated with cells.

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