Relation of mammalian sperm chromatin heterogeneity to fertility

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Science  05 Dec 1980:
Vol. 210, Issue 4474, pp. 1131-1133
DOI: 10.1126/science.7444440


Flow cytometry of heated sperm nuclei revealed a significant decrease in resistance to in situ denaturation of spermatozoal DNA in samples from bulls, mice, and humans of low or questionable fertility when compared with others of high fertility. Since thermal denaturation of DNA in situ depends on chromatin structure, it is assumed that changes in sperm chromatin conformation may be related to the diminished fertility. Flow cytometry of heated sperm nuclei may provide a new and independent determinant of male fertility.

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